W Panama  

Perched in Panama City's business district, this bold hotel disrupts the skyline and keeps you minutes from the action. It's about 30 minutes from Tocumen International Airport, 10 minutes to the San Francisco dining scene, 15 minutes to historic Casco Viejo and a five-minute stroll to La Cinta Costera. Centrally located and pet-friendly, it's an easy base for both business and family-friendly city breaks.

Rooms are sleek and modern with high-contrast décor inspired by local culture. The 203 air-conditioned guestrooms come with iPod docking, minibars (some complimentary items), espresso makers, rainfall showers, safes and complimentary bottled water. Design-forward public spaces pair bold color with local touches for a lively, Instagram-ready vibe.

Soak at the AWAY Spa or unwind in one of three spa tubs, then hit the WET Deck outdoor pool and poolside bar. There's an indoor pool, sauna, massage rooms, health club/fitness center, hair salon, nightclub and concierge services. Snacks and coffee are on-site, 24-hour room service is available, and buffet breakfast is offered for a fee. Free valet parking is provided.

Big on meetings: 10,452 sq ft of event space with multiple meeting rooms and a 24-hour business center. Add express check-out, dry cleaning, concierge and wireless internet access (surcharge) for a smooth work stay.

Two on-site restaurants (including Moró, which spotlights local flavors) and La Cajita for craft cocktails keep the menu local and lively. There's also a coffee shop/café, two bars/lounges and 24-hour room service—perfect for late arrivals or poolside cravings.