Hampton Inn Cape Girardeau I 55 East  

In Cape Girardeau, just off I‑55 at William Street, this hotel puts you a quick drive from Saint Francis Medical Center, Southeast Missouri State University and family attractions like Cape Splash. Shawnee National Forest and the Mississippi River are also within easy reach, and the municipal airport is about 6 miles away. Family-friendly and conveniently located near shopping and dining, it’s a practical base for riverfront and outdoor outings.

The property offers 86 guestrooms with in-room refrigerators and microwaves, flat-screen TVs, desks and safes. Private baths have shower/tub combos, complimentary toiletries and hair dryers. Rooms are warm and straightforward, with options for cribs/infant beds and accessible features like an elevator and on-site playroom space for kids.

Take laps in the heated indoor pool or hit the fitness center to start the day. There’s a picnic area and a banquet hall for events. Complimentary wired and wireless internet is available throughout and free self-parking makes arriving easy.

A business center with computer terminals and printing keeps work moving. Complimentary wired internet and lobby newspapers are available, plus laundry/dry-cleaning services and luggage storage for longer stays.

Fuel up with a complimentary hot breakfast served daily—think fresh-baked waffles, eggs and rotating hot items—and grab On the Run breakfast bags Monday–Friday if you’re in a hurry. There’s a nightly cookie hour with warm cookies and milk, plus an on-site snack bar/convenience option. Several restaurants are within walking distance in the adjacent shopping complex.