21c Museum Hotel Louisville

On Louisville’s historic West Main Street in Museum Row. This boutique, pet-friendly art hotel sits in the heart of downtown, steps from the Louisville Slugger Museum, Muhammad Ali Center, Kentucky International Convention Center, KFC Yum Center and Fourth Street Live!.

An award-winning 91-room property that doubles as a multi-venue contemporary art museum. Rooms blend modern comfort with playful touches—premium bedding and down comforters, minibars, iPod docks, 50-inch LCD TVs, bathrobes and designer toiletries. The hotel’s iconic Red Penguin and rotating installations keep the vibe edgy and gallery-focused.

Relax in a full-service spa with massages, sauna and steam rooms. Stay active in the fitness center and yoga area. Concierge, gift shop/newsstand and a tour desk make planning bourbon trail or gallery outings easy. Complimentary wired and wireless internet is available throughout, and limo/town car service can be arranged.

5000 sq ft of conference and event space with meeting rooms and a 24-hour business center. Complimentary wired internet and limo/town car service support meetings and VIP arrivals.

Home to the acclaimed Proof on Main restaurant and an on-site bar/lounge. Limited-hour room service is available, and full breakfasts are offered daily for a fee.