21C Museum Hotel St Louis

In the heart of downtown St. Louis on Locust Street, a short walk from the City Museum and CITYPARK stadium. This boutique hotel sits in a reimagined 10‑story Renaissance Revival YMCA building, minutes from Union Station, Gateway Arch National Park and other downtown highlights. Pet-friendly and perfectly placed for museum- and stadium-side stays.

Expect contemporary art around every corner—more than 14,000 sq ft of exhibition space is woven into the hotel. The property blends historic architecture with modern rooms featuring espresso makers, flat-screen TVs, private bathrooms and seating areas. A full-service Locust Street Athletic & Swim Club and wellness center add a sporty, stylish edge to the vibe.

Indoor pool, steam room and a full fitness center keep mornings active; spa and wellness services help you unwind. Complimentary Wi‑Fi, concierge services and on-site parking make stays easy. Art-filled public spaces and extensive meeting/exhibit areas give the place a gallery-meets-hotel feel.

More than 14,000 sq ft of meeting and event space plus meeting rooms and a business center. Complimentary wireless internet and 24-hour front desk support make this a solid pick for downtown events and work trips.

On-site dining includes the Idol Wolf restaurant and the Good Press café for coffee and snacks. There’s a bar/lounge for evening drinks, a café for grab-and-go items, and limited room service. Cooked-to-order breakfasts are offered daily (fee applies).