21C Museum Hotel St Louis  

In the heart of downtown St. Louis, steps from major museums and the stadium district. Located on Locust Street, the boutique hotel sits within easy walking distance of the city center and nearby parks. Pet-friendly and walkable to nightlife and attractions.

Housed in a reimagined historic Renaissance Revival building, this 173-room boutique property blends contemporary art with classic architecture. Expect gallery-style common spaces, art on every floor, and rooms with A/C, flat-screen TVs, seating areas and private bathrooms stocked with complimentary amenities.

Dive into an indoor swimming pool or sweat it out at the full-service wellness center and gym. Enjoy a steam bath and spa treatments, grab a drink at the bar, and use on-site parking. Accessible facilities and elevator access make the place easy to navigate.

More than 14,000 sq ft of exhibition and meeting & event space is woven through the property, with conference halls, meeting rooms and presentation facilities for events of all sizes. Free Wi‑Fi across the property keeps you connected.

On-site restaurant and café serve casual to refined bites and drinks in arty settings. Stop in for coffee, cocktails or a sit-down meal that pairs local flavors with contemporary twists.